Selected projects & publications.

Our experts have delivered work of many scopes, sizes and budgets. These examples show how our approach plays out in practice.

Clinical trials2007–2008

Statistical analysis plans for a global oncology program

Designed and developed statistical analysis plans for a vast clinical-trial program for the oncology department of a large pharmaceutical company in New Jersey, one of the top 10 internationally.

200trials
50centers
Clinical trialsDecision analysis

Laparoscopic vs. abdominal hysterectomy

A randomized clinical trial and prospective cohort study compared surgical outcomes. We developed expert guidelines on the effects of shared decision-making and conducted the statistical analysis with repeated measures, nonparametric statistics and stratified analysis. A decision-tree model compared three surgery types.

8outcome variables
OncologyBayesian

Breast cancer: tamoxifen vs. chemotherapy

A stochastic decision-tree model evaluated the survival benefit of adding chemotherapy to tamoxifen. We developed the Bayesian statistics for the model and ran the analysis of variance, correlation and nonparametric analyses.

Real-world evidenceMetabolic

EHR studies in diabetes and vitamin D deficiency

Managed large electronic-health-record datasets and applied multivariate and regression modeling to explore predictors of biochemical outcomes in type 2 diabetes, with sponsor-ready SAPs and outputs for international collaborations.

Real-world evidenceConsumer health

Evidence program for an OTC respiratory-health product

Led statistical strategy and data management for observational and pragmatic studies with quality-of-life and patient-reported endpoints, presenting findings to executive stakeholders to support product-lifecycle decisions.

Occupational healthU.S. DOE / NIOSH

Paducah gaseous diffusion plant workers study

A U.S. Department of Energy study funded by NIOSH of a fifty-year worker cohort, assessing cause-specific mortality and cancer incidence. Our role included preference analysis for roster development and quality assurance of data management in SAS.

Predictive analytics2009–2011

Forecasting asthma and allergy cases in schools

For a top-10 U.S. health insurer, we combined hourly measures of 10 air-pollution factors and twice-daily measures of 24 upper-air factors over three years to forecast asthmatic and allergic cases in Pennsylvania public schools.

1,200schools
44counties
Data miningPublished

BMI patterns among Pennsylvania schoolchildren

Data mining of large school-health datasets (Pre-K to Grade 12) revealed body-mass-index patterns; follow-on work modeled transitions between BMI categories using simulation. Findings appeared in the Journal of School Health and the American Journal of Public Health.

SimulationPublished

Healthcare reform: public concern and projected repercussions

Sentiment analysis and web-content analysis of online news and social media, plus stochastic-tree simulation of QALY outcomes under funding and coverage scenarios for people with multiple chronic conditions.

Market basket analysisPublished

Multiple and substitute addictions among adolescents

A retail data-mining technique, market basket analysis, was applied to reveal gateway and substitution patterns in prescription-drug misuse among twelfth graders (Journal of Addiction Medicine).

School healthMulti-year

School-health portal analytics for a health-services partner

Collaborated for three years with health-care organizations and the state of Pennsylvania on research using de-identified K-12 data from a coordinated school-health portal serving about 1,100 school buildings.

Development1995–1996

Old Cairo Tanneries relocation

Feasibility study, statistics and business plans for relocating the tanneries district from Old Cairo to Badr City, for Egypt’s Ministry of International Cooperation, with funding from Japan.

$106Mproject funding
DevelopmentIndustrial sector

Assessing Egyptian industries’ needs to enter international markets

Investigation of development constraints to identify priorities and strategies for strengthening clients’ capabilities to compete globally, including MIS development and statistical analysis.

700factories
5industrial fields
Market research

Market study for a household-appliance manufacturer

Survey-based study of existing and potential customers and dealers to understand demographics, purchasing patterns, decision factors, brand awareness and competition for Zanussi Co. of Egypt.

Policy researchFord Foundation

Small-enterprise informality and regulatory reform

Economic and statistical analysis of how regulation affects small enterprises in leather, garment, metal and wood sectors.

$150Kfunding
450small businesses
DevelopmentUS-AID

Business incubators & training block grants

Feasibility study and business plans for two pilot business incubators on the Suez Canal ($3.5M), and design and operation of a management information system to monitor the US-AID Training Block Grants activity across Egypt ($5M).

$8.5Mcombined funding
Publications

Selected refereed publications

Our team’s work has appeared in peer-reviewed journals and international conference proceedings.

  1. Use of Data Mining to Reveal Body Mass Index (BMI): Patterns among Pennsylvania Schoolchildren, Pre-K to Grade 12. Journal of School Health, 2013; 83(2):85–92. PMID 23331267.
  2. Trends in BMI and Prevalence of Extreme High Obesity among Pennsylvania Children and Adolescents, 2007–2011: Promising but Cautionary. American Journal of Public Health, 2014. PMID 24524514.
  3. Air Pollution Indicators Predict Outbreaks of Asthma Exacerbations among Elementary School Children. Journal of Environmental Monitoring, 2012; 14(12):3202–3210. PMID 23147442.
  4. Upper-Air Observation Indicators Predict Outbreaks of Asthma Exacerbations among Elementary School Children. Journal of Asthma, 2012; 49(5):464–473. PMID 22574718.
  5. Multiple and Substitute Addictions Involving Prescription Drugs among Twelfth Graders: Gateway Model Revisited with Market Basket Analysis. Journal of Addiction Medicine. PMID 24440894.
  6. Attenuated PTH responsiveness to vitamin D deficiency among patients with type 2 diabetes and chronic hyperglycemia. Diabetes Research and Clinical Practice, 2017; 128:119–126. PMID 28475987.
  7. Comparing niraparib versus platinum-taxane doublet chemotherapy as neoadjuvant treatment in newly diagnosed HRD stage III/IV ovarian cancer: findings from cohort C of the OPAL phase 2 trial. Gynecologic Oncology, 2026; 212:173–180.
  8. Impact of post-ASCT maintenance therapy on outcomes in patients with newly diagnosed multiple myeloma in Connect MM. Blood Advances, 2018; 2:1608–1615.

Books

Contemporary Issues in Public Health in North Africa and the Middle East (Nova Science Publishers). Chapters address diabetes, hepatitis C, sexually transmitted infections, drinking water and gender discrepancies in health, going beyond the HIV/AIDS focus of much regional scholarship.

A second volume on healthcare reform in the USA, covering sentiment analysis of online media and stochastic simulation of reform scenarios, is in process.

Refereed proceedings

Data Mining and Simulation conferences (WORLDCOMP’12 and ’13, Las Vegas): healthcare-reform simulation, online-news content analysis and Twitter-based early warning of norovirus outbreaks.

Have a similar challenge?

We’d be glad to discuss how our experience applies to your project.